Contact
Education
| 2022–pr | PhD in Biology, on the activation mechanism of VPS34 complexes during autophagy, under the supervision of Roger L. Williams, Protein & Nucleic Acid Division of the MRC Laboratory of Molecular Biology (LMB) and at the University of Cambridge (Lucy Cavendish College), UK. |
| 2019–2021 | MSc in Structural Biology both at the Université Paris-Saclay and at the ENS Paris-Saclay, obtained with high distinction (rank 1/17) |
| 2019 | Biology bachelor (Licence) at the Grenoble Alpes University, International programm, obtained with high distinction (rank 1/173) |
Work Experience
| 2021-2022 | “Mechanistic, structural and functional characterisation of VPS34 activators”, Protein & Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK. Dir. Dr. Roger Lee Williams FRS FMedSci (9 months) |
| 2022 | Participation to the 3rd International Conference on HDX-MS, Francis Crick Institute, London, UK (3 days) |
| 2021 | “Regulation of small GTPase Rac1 by the ubiquitin ligase Hace1” Team Biologie Structurale des petites GTPases at the LBPA, ENS Paris-Saclay, France. Dir. Dr. Agata Nawrotek-Maalouf & Dr. Jacqueline Cherfils (6 months) |
| 2019 | “Differential analysis of tumoral genes expression” TIMC-IMAG laboratory, Grenoble, France. Dir. Dr. Daniel Jost . Work on a R package (3 weeks) |
| 2018 | “Characterisation of nanobodies-membrane protein interaction” Institut de Biologie Structurale, Grenoble, France. Dir. Pr. Eva Pebay-Peyroula. Experimental techniques used : ELISA, SPR, Western Blot, affinity chromatography, radioactive phosphate transport test (6 weeks) |
| 2017 | “In vitro nucleosomes reconstitution” Laboratoire de Physiologie Cellulaire et Végétale , CEA Grenoble, France. Dir. Dr. Chloe Zubieta. Experimental techniques used : SDS-PAGE, Western Blot, affinity chromatography, SEC (4 weeks) |
Publications
| Gong, G. Q., Anandapadamanaban, M., Islam, M. S., Hay, I. M., Bourguet, M., Špokaitė, S., ... & Williams, R. L. (2024). Making PI3K superfamily enzymes run faster. Advances in Biological Regulation, 101060. [DOI] |
| Swamynathan, M. M., Kuang, S., Watrud, K. E., Doherty, M. R., Gineste, C., Mathew, G., ... & Trotman, L. C. (2024). Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function. Science, 386(6720), eadk9167. [DOI] |
Languages
| French: Native speaker |
| English: CAE Certified C2 (fluent) |
| German: Certified B1 Level (independent user, good working knowledge) |
Communications
| Dessus, A. (2022). Activation of Autophagy by small molecules. Gif-sur-Yvette : Multidisciplinary junior congress, GS MRES, Université Paris-Saclay |
| Dessus, A. (2021). Regulation of Small GTPase Rac1 by ubiquitinylation. Communication to the “membrane transporters” team, Institut de Biologie Structurale, Grenoble, France |
| Dessus, A. (2018). Inhibition of the APT by antibodies. Communication to the “membrane transporters” team, Institut de Biologie Structurale, Grenoble, France |
Knowledge
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Additional Skills
| Adept in Cryosparc, Relion5, R and ImageJ, knowledgeable in ChimeraX, Pymol. |
| Total of 18 months of internship and 500 hours of praticals in biology. |
Other Achievements
| 2017 | Musical studies diploma (oboe), conservatoire d’Aix-les-Bains, France |